EXPERIMENTAL STUDIES ON HEMOLYTIC DISEASE
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概要
- 論文の詳細を見る
1. By peroral and parenteral giving of anti-erythrocyte serum and anti-serum serum and parenteral giving of anti-bone marrow serum, pathologic changes very similar to the human hemolytic disease were produced in newborn rats, but failed to do so in the peroral and parenteral giving of anti-liver serum.2. Pathologic changes very similar to the so-called hemolytic jaundice were demonstrated in adult rats by subcutaneous injection of anti-erythrocyte serum, but not by its peroral giving except for a slight increase of erythroblasts in the bone marrows of all cases and increase of erythroblasts in the bone marrows of all cases and slight anemia in one case.3. When anti-erythrocyte serum was given to newborn rats perorally, refined vaccine virus and refined vaccine virus plus vitamine C could inhibit the appearance of jaundice completely, but not when that anti-serum was given subcutaneously.4. When anti-erythrocyte serum was given to adult rats, the appearance of jaundice could not be completely inhibited, while refined vaccine virus and cystine inhibited it to a certain degree.5. The erythroblasts in circulating blood consisted of normoblasts of almost the same stage of development and their protolasma were orthochromatic or polychromatic except for some which were basophylic The anisocytosis of the red cells was conspicuous and especially a remarkable increase in the number of microcytes was noticed.
- The Keio Journal of Medicineの論文