STUDIES ON THE ACTIVATION OF ORGANIC ARSENICAL COMPOUNDS (PART II)
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概要
- 論文の詳細を見る
(1) By studying the action of plasma against Oxo-HCl, it has been discovered that plasma increases or decreases its efficiency according to the quantity used.(2) This fact allows the presumption that there exists, in plasma protein fraction, a part which increases its efficiency and parts which decrease its efficiency. This efficiency increasing part is eu-Globulin; the efficiency decreasing parts are albumin and pseudoglobulin.(3) With the addition of eu-globulin the efficiency of Oxo-HCl is increased, the toxicity is decreased slightly, and the chemotherapeutic index grows 3 times as that of Oxo-HCl alone.(4) This action of eu-globulin requires some time for reaction after mixing. From this fact it is inferable that a compound is found by a loose combination between Oxo-HCl and the separate acid group of the amino acid constructing eu-globuline.(5) Oxo-HCl obstructs red blood cell cholinesterase, and also inhibits plasma cholinesterase. From this fact, it is deduced that one cause for side reaction of Oxo-HCl might lie in the inhibitory action against cholinesterase.(6) When cysteine or Benadryl is mixed with Oxo-HCl, the inhibitory action against cholinesterase is decreased. From this, it is thought that anti-histamine drug passosses an action which markedly lowers the toxicity of Oxo-HCl.(7) The action of anti-histamine drug (Benadryl and pyribenzamine) which lowers the toxicity of Oxo-HCl is superior to that of cysteine and glutathione, and is equal to that of BAL. And, as the action which lowers its efficiency is less than that of SH compounds, the author thinks, the anti-histamine drug are to be given proper attention as the toxicity reducing drug against Oxo-HCl.Acknowledgement. The author is indebted to T. Mizuma and K. Takahashi for chemical experiments.
- The Keio Journal of Medicineの論文