ON THE CHANGES OF PLASMIN ACTIVITY CAUSED BY RADIATION TREATMENT IN CANCER PATICETS AND EFFECTS OF ANTIPLASMIN (IPSILON) ADMINISTRATION
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概要
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On seventy cancer patients, all of whom were to receive radiation therapy for the first time, the blood and the urine were taken once a week, before and during radiation treatment, and the changes in the value of fibrinogen, in the plasmin value of the plasma, and the urine were carefully examined with the following results:1) With a large number of cancer patients plasmin activity was found already elevated before irradiation, but in two-thirds of the cases further activation became evident after irradiation.2) When observed according to the irradiated location, the degree of activation of plasmin was roughly in the order of upper abdomen, chest, head and neck and lower abdomen. The frequency and the time of appearance of plasmin activation almost agreed, in most cases, with the appearance of radiation sickness. The fact very well suggests that close relationship exists between plasmin activation and radiation sickness.Thirtythree similar cancer patients were treated daily with large amounts of Ipsilon throughout the duration of the irradiation with the following result:1) It proved effective in stopping the plasmin activation, especially in arresting the activation of plasmin in the plasma and in the urine.2) It was also found effective in arresting radiation sickness., In only 3 cases (9.1%) out of the 33 were radiation symptoms noted.3) Decrease of the leucocyte count was also prevented to a certain degree by the treatment.4) No side effects were perceived from daily 3 g administration of Ipsilon in divided doses.
- The Keio Journal of Medicineの論文