MEMBRANE PROTEIN BINDING ANTIBODY FOUND IN VARIOUS PATIENTS OF PROPOSED "MEMBRANE DISEASE"

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概要

• 論文の詳細を見る

• Isolated rat muscle and human erythrocyte membranes as antigens have been disaggregated with sodium dodecyl sulfates (SDS).A positive anti-membrane factor detected with l'électrosynérèse (Bussard) was demonstrated in 12.8% of the sera from myasthenia gravis patients and 100% of the systemic lupus erythematosus (SLE) patients. Various other dis-eases, such as collagen diseases, malignant tumours and chronic infections, had less than 50% positive precipitin reactions, and 200 healthy individuals were all negative. The membrane solution, after reducing the SDS to a concentration of less than 2±10-3 M, always gave a positive precipitin reaction against the sera of SLE patients. These finding suggest a new clinical entity of "Membrane Dis-ease."

• The Keio Journal of Medicineの論文

著者

• NAKATA Yasunari

  the Second Department of Internal Medicine, Okayama University Medical School

• ARIMORI SHIGERU

  The Second Department of Internal Medicine, Okayama University Medical School

関連論文

• OK-432 Induces Production of Neutrophil Chemotactic Factors in Malignant Pleural Effusion
• MEMBRANE PROTEIN BINDING ANTIBODY FOUND IN VARIOUS PATIENTS OF PROPOSED "MEMBRANE DISEASE"

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