AN ELECTRON MICROSCOPIC OBSERVATION ON THE CYTOLOGICAL CHANGES IN THE EXPERIMENTAL DRUG-INDUCED LIPIDOSIS

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概要

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• The fine structural changes induced by 4, 4'-diethylaminoethoxy hexestrol dihydrochloride(DH)-a coronary vasolidator-in the rat liver and pancreas were studied. The cytoplasmic change caused by the daily administration of DH was characterized by the appearance of numerous myeloid inclusion bodies. The myeloid bodies appeared at first near the Golgi complexes in the early stage of treatment and increased in number, and at the same time, the fusion of myeloid bodies occurred in proportion to the period of treatment. The myeloid bodies were tentatively classified into following four types: whorls of membrane (type I), dense bodies with a regular periodicity (45-55Å), such as finger-printed structure (type II), labyrinthine aggregates of smooth membrane and reticular internal structure surrounded by membranes (type III) and crystalline bodies showing an internal regular lattice pattern (type IV). There were also many intermediate types among them in the case of long term administration of DH. It is suggested that type III, IV myeloid bodies are formed through the stage of type I or type II myeloid bodies and that type I and type II myeloid bodies appear originally caused by DH ad ministration. The myeloid bodies are assumed to be produced by the processes that the lipid metabolism is disturbed by DH itself and abnormal metabolites are formed and then, they are uptaken and accumulated in the lysosomes. After intralysosomal digestion, more resistant components of lipid remain and are condensed in the lysosomes. These residues, rich in phospholipids and free cholesterol are probably represented as myeloid structures. These cellular changes induced by DH administration were reversible in rats. The processes of cellular recovery and disappearance of myeloid bodies in rat liver and pancreas were also observed.

• The Keio Journal of Medicineの論文

著者

• Tashiro Yukio

  Department Of Pathology Yokohama Rosai Hospital

• TASHIRO YUKIO

  Department of Pathology, School of Medicine, Keio University

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• AN ELECTRON MICROSCOPIC OBSERVATION ON THE CYTOLOGICAL CHANGES IN THE EXPERIMENTAL DRUG-INDUCED LIPIDOSIS

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