HL-A AND MLC ANTIGENS IN THE JAPANESE POPULATION
スポンサーリンク
概要
- 論文の詳細を見る
Two new HL-A specificities, which seem to be characteristic to Japanese, were found. Sa 1 antigen, associated with W22, behaved as a new HL-A antigen in the second segregant series. The other one, 4c* component, which seems to be somewhat different from the W5-W18 complex in Caucasians, was detected from the analysis of 63 HL-A 5 associated antisera mainly obtained from Japanese parous women.Inheritance of atopic diseases and its linkage to HL-A haplotypes were shown from the analysis of seven families, in which atopic diseases occurred in more than two members.Close association between HL-A 5 and Behcet's disease was also observed.Separate MLC loci, which are closely linked to the HL-A locus, were suggested from the MLC and HL-A studies in some families.To determine the reference LD homozygous cells for the establishment of the MLC antigenic specificities among Japanese, children from a first-cousin marriage, and the HL-A homozygous children from parents who share an MHC haplotype, were extensively examined. Four LD homozygous cells were obtained. Studies on the distribution of these MLC antigens among Japanese and the possible existence of linkage disequilibrium between HL-A and MLC alleles are now in progress.
- The Keio Journal of Medicineの論文
著者
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Nakayama Eiichi
Department Of Immunology Okayama University Graduate School Of Medicine And Dentistry
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Yakura Hidetaka
Department Of Immunology And Signal Transduction Tokyo Metropolitan Institute For Neuroscience Tokyo
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Aizawa Miki
Department of Pathology, Hokkaido University School of Medicine
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Itakura Katsuaki
Department Of Pathology Asahikawa Medical College
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YAKURA HIDETAKA
Department of Pathology, Hokkaido University School of Medicine
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NAKAYAMA EIICHI
Department of Pathology, Hokkaido University School of Medicine
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