TIEREXPERIMENTELLE UND KLINISCHE UNTERSUCHUNG ZUR WIRKUNG VON COENZYM A AUF DIE FETTELIMINATION BEI DER FETTLEBER

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Based upon the experimental results in KK and ddY/S-mice, it has become clear that a combination of Coenzyme A and Adenosine triphosphate exercises a favorable influence on treatment of the fatty liver. Forty one patients have been complaining of general fatigue more than one year. Their bodyweight exceeded slightly the standard in their own age. Physical examination revealed slight enlargement of the liver. Laboratory findings: hyperbetalipoproteinemia, hypercholesterinemia, hyperbetaglobulinemia, pathologic BSP-retention, slight elevation of cholin esterase and transaminaseactivity. Glucose toleranse test with 50g resulted in latent or manifest diabetic curve. Immunoreactive insuline (IRl) was also estimated. Liver biopsy: fatty liver. The treatment with a combination of 8mg CoA and 30mg 219 ATP daily in the form of intramuscular injection was introduced into the medical treatment when needle biopsy of the liver revealed steatosis hepatis histologically in these patients. After therapeutic duration of 6 months, laboratory findings as well as histological features of the biopsied liver specimens were improved. Therefore, it can be said that simultaneous i.m. injection of CoA and ATP brings a favorable effect not only on the laboratory findings but also on the histological changes of the fatty liver with diabetic change.