EFFECT OF AN ANORECTIC AGENT, AN 448 ON WEIGHT REDUCTION AND PLASMA LIPIDS

概要

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A new appetite suppressant AN 448 was given to 41 adult obese outpatients to investigate its effect on weight reduction with special references to the plasma lipids. Twelve of them dropped out within 4 weeks because of side effects or unknown reasons. The remaining 29 subjects lost their weights with an average reduction of 2.6 kg in a month and 5.9 kg in 3 months. Slight decrease in serum cholesterol, triglyceride, free fatty acids, phospholipid were also observed 1 month after administration.Six healthy male nonobese volunteers were used to evaluate the shortterm effect of AN 448 on plasma lipids. Each subject received in randomized order a single oral dose of AN 448 1mg or placebo at five-day interval. Free fatty acids significantly rose 180 minutes after AN 448 administration. Cholesterol and triglyceride showed no significant alterations.The fact that AN 448 enhances the lipolysis in adipose tissue with concomitant diminishing cell size and increases free fatty acids in the plasma suggests the possibility that it would lessen the effect of body weight reduction on serum triglyceride level.
The Keio Journal of Medicineの論文