急性妊娠脂肪肝(acute fatty metamorphosis of pregnancy)の一例

概要

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This disease entity was first proposed by Sheehan in 1940, since then, additional cases have been reported. It has been known that the maternal mortality is very high and survival case reports are less than twenty cases. Recently, we had the chance to see the typical clinical course of the survival one and the detail clinical picture with some discussions on practice, was reported.<BR>CASE. A 29 y. o. primipara who had the preceeding gastrointestinal troubles for two weeks, was admitted to our hospital because of the premature delivery in 37 weeks gestation. After delivery, her condition got worse suddenly and jaundice, convulsion, hematemesis and coma developed succeedingly. After several critical days, her general condition got better rapidly. The liver biopsy under laparoscopy was done on her 23 hospital day, which revealed the fine fatty vacuolation of hepatocyte in centrolobular region, charactaristic of this disease.<BR>She was discharged after 41 days hospitalization with no specific abnomality except slight ALP elevation.
社団法人日本肝臓学会の論文