Effects of Inline Filtration on Delivery of Gentamicin at Various Flow Rates.

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The effects of inline filtration on delivery of gentamicin (GM) in the pediatric field were studied. The filter sets (Pall 0.20μm. JMS 0.20μm, and IVEX 20.22μm) were studied using a simulated system. 10mg of GM was injected into the system containing 5% dextrose in water (flow rate: 50ml/hr, 10ml/hrand 2ml/hr) with horizontal and vertical settings of the inline filters. In caseof 50ml/hr, delivery of GM of Pall showed nearly the same delivery pattern as compared with no filter setting. However, JMS and IVEX 2 showed little differences. In case of 10ml/hr and 2ml/hr those differences became more signifi-cant. Delivery of GM was influenced by the priming volume of the filters, increasingly so at slow flow rates. Filter settings also influenced the delivery of GM. Furthermore, with regards to the results of the Vitamin K2 delivery and the technetium radiotracer method, JMS and IVEX 2 filters were observed to have some stagnation of drugs in the filter. Not only priming volumes of the filters affect delivery of drugs, filter designs also have an influence. The use of the inline filters is important in the pediatric field, but their charactaristics for drug delivery pattern should be considered.