HISTOCHEMICAL STUDIES OF PULMONARY HYALINE MEMBRANES
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概要
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1. No typical difference between human newborn and guinea pig in the pulmonary hyaline membrane was found histochemically as far as we have examined.2. We used Bloxsom apparatus with low oxygen concentration (60%) in the experimental oxygen poisoning of the guinea pig, (average animal weight 822 grams). Highly thick hyaline membranes were found. Average living time was 189 hours.3. Hyaline membranes of human newborn and guinea pig consist of muco-proteins coming from blood plasma, i.e. the serum mucoproteins, seromucoid and seroglycoid.4. These mucoproteins were histochemically similar to fibrinoid of placenta except several ordinary stainings (Gram-weigert's method. PTAH, Masson's trichrome stain AZAN).5. The change of permeability in pulmonary capillaries was considered to be the main cause in making hyaline material inside the alveoli because hemo-globin was not always present and the serum mucoproteins were the main substance of the hyaline membrane.6. The hyaline membranes of human newborn and guinea-pig contained small amount of nucleo protein, neutral fat and phosphatid besides the main substance of mucoproteins. The membranes were not made by simple origin like the alveolar epithelium or collagen. We supposed thee membranes consist of coagulated serum mucoproteins.7. Amniotic fluid might be a possible cause of the hyaline membrane just like highly concentrated oxygen in the guinea pig, but it was not the main substance of the membranes.I am grateful to Dr. G. W. Anderson for his generous cooperation and suggestions.
- The Keio Journal of Medicineの論文