Assessment of Growth Hormone Secretion in Children
スポンサーリンク
概要
- 論文の詳細を見る
Growth hormone (GH).is secreted in a pulsatile way during the whole life under the reciprocal influence of somatostatin and GH-releasing hormone (GHRH). It mediates many effects by stimulating production of insuline like growth factor I (IGF I).in liver and other tissues, but IGF I is also regulated by the nutritional state. Women secrete more GH than men, and older men and women less than young women. This suggests importance of estradiol in regulating secretion. Sex hormone effects are also demonstrated by the increment of GH and IGF I at puberty, which is an amplitude-modulated phenomenon. Classic metabolic studies have shown that patients with GH-deficiency retain more nitrogen in response to a given dose of exogenous hGH than normal subjects. The use of the stable isotope 15N has simplified such studies. In GH-deficient patients, there was with this technique a marked positive hGH-induced balance change. In girls with Turner syndrome (as example of subjects with normal GH-secretion), balance change was less marked with the same dose. Girls with Turner syndrome, who were given a double hGH-dose showed a response in the same range as that in the GH-deficient patients with the lower dose. A conclusion from this is that patients with normal GH-secretion need higher doses to obtain a similar response, than patients with GH-deficiency. The dosage in such patients will have to be selected individually, and needs to be about twice or three times as high as in GH-deficient patients.
論文 | ランダム
- 実係数の0-1ナップザック問題を最大価値経路問題に帰着させて解く方法
- β線吸収式のSPM計のフィルターを用いたSPM高濃度時の元素状炭素粒子の広域観測
- 気候変動問題と人為起源エアロゾルの直接効果
- 「第4回エアロゾル国際会議」の報告
- 3a-LE-13 Gd(Al_Cu_x)_2の伝導電子部分波 : 4f電子交換相互作用