The human immunoregulatory T cell circuit: Recent progress and its clinical implications.

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概要

• 論文の詳細を見る

• The present studies indicate that both the heterogeneity and functional programs of human T lymphocytes can be distinguished. Within the T4 subset, which is responsible for inducer/helper functions in T-T, T-B and T-macrophage interactions, discrete subpopulations are present; T4 cells bearing the 2H4 molecule (T4+2H4+) induce T8+suppressor effector cells, and T4 cells bearing the 4B4 molecule (T4+4B4+) induce help for B cell Ig synthesis. Within the T8 subset are precursors and effector cells responsible for both suppressor or cytotoxic function. It is now evident that T4 cells show a preferential interaction with class II MHC determinants on accessory or target cells, whereas T8 cells have a preference for class I determinants. Furthermore, the T4 and T8 glyco-proteins themselves may function as associative recognition structures in such functions. Recent work has elucidated the role of the T3-Ti antigen receptor complex which is involved in both antigen recognition and T cell activation. The T3 molecule, a nonpolymorphic determinant is membrane-associated with the 90 KD Ti heterodimer, a highly polymorphic structure with both constant and variable regions, making up the T cell receptor for antigen. It is believed that these unique cell surface glycoproteins will have a critical role in regulating the nature and intensity of the immune response. The clinical relevance of these cell surface glycoproteins in human diseases also will be discussed.

• The Keio Journal of Medicineの論文

著者

• Schlossman Stuart

  Division Of Tumor Immunology Department Of Cancer Immunology And Aids Dana-farber Cancer Institute ;

• 森本 幾夫

  Division of Tumor Immunology, Dana-Farber Cancer Institute Department of Medicine, Harvard Medical School

• Schlossman Stuart

  Division of Tumor Immunology, Dana-Farber Cancer Institute Department of Medicine, Harvard Medical School

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• B cell co-receptors regulating T cell-dependent antibody production in common variable immunodeficiency : CD27 pathway defects identify subsets of severely immuno-compromised patients
• The human immunoregulatory T cell circuit: Recent progress and its clinical implications.

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