Chondroitin 6-sulfate proteoglycans constructing hemopoietic microenvironment in bone marrow.

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概要

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• i) Rabbit femoral bone marrow was determined to contain GAGs equivalent to 220mg of hexuronate per femur and the molecular species of those were identified to be chondroitin 6-sulfate (79%) and hyaluronic acid (16%). ii) The chondroitin 6-sul-fates occurred in situ as three species of PGs with estimated molecular weights of 8, 300, 46, 000 and 16, 000, in ratio of approximately 2/5/3, and were localized only in extra-cellular matrix of the bone marrow. iii) These chondroitin 6-sulfate PGs were synthe-sized by the cells within the bone marrow and not brought out with peripheral blood cells or secreted as plasma components. iv) Together with these results, it is strongly suggested that the three species of PGs are synthesized by the stromal cells in the bone marrow and involved in construction of the extracellular matrix unique to bone marrow. These PGs present in the bone marrow were considered to play an important role in regulation of hemopoiesis as proposed by Dexter et al.3

著者

• 小栗 佳代子

  Clinical Research Institute, National Nagoya Hospital

• 岡山 暎子

  Clinical Research Institute, National Nagoya Hospital

• Caterson Bruce

  Department fo Biochemistry, West Virginia University

• 岡山 実

  Clinical Research Institute, National Nagoya Hospital

関連論文

• Chondroitin 6-sulfate proteoglycans constructing hemopoietic microenvironment in bone marrow.

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