The effect of electroconvulsive therapy on plasma cyclic-AMP, non-esterified fatty acid, tryptophan and tyrosine in depression.
スポンサーリンク
概要
- 論文の詳細を見る
Electroconvulsive therapy (ECT) was applied to nine endogenous de-pressed patients and the concentrations of cyclic-AMP (c-AMP), free (non-albumin bound) tryptophan, total tryptophan, non-esterified fatty acid (NEFA) and tyrosine in the plasma were measured before and after the first single ECT. As for six patients that could be followed after a course of ECTs, the change of these components and clinical assessments with rating scales was also measured. The content of c-AMP was significantly increased at 1 min, 5 min, 10 min and 30 min after the first single ECT and returned to 121% on the average by 1 hr. As to the maximum content of free trypto-phan of each patient from 1 min to 10 min after ECT, a significant increase was noted. Total tryptophan levels were significantly decreased at 5 min and 10 min after the first single ECT and gradually returned to the original level by 1 hr. The content of tyrosine was significantly increased just after the first single ECT and, conversely, a significant decrease was noticed at 1 hr after ECT. NEFA was significantly decreased at 1 min and 5 min after the first single ECT. As for the six patients that could be followed concerning the changes of various components and clinical assessments, all six patients showed dramatic and significant improvement in both subjective and objec-tive rating scales. Percent free tryptophan tended to increase significantly in these patients, but there was no significant change in c-AMP, total trypto-phan, NEFA, and tyrosine values.
- The Keio Journal of Medicineの論文