NEUROCHEMICAL AND BEHAVIORAL STUDIES ON THE EXPERIMENTAL PHENYLKETONURIC RATS
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概要
- 論文の詳細を見る
Neurochemical changes and discriminative learning ability were investi-gated on experimental phenylketonuric rats (PKU rats). PKU rats were fed a diet containing 7% L-phenylalanine from 22nd day of age for several months. Some rats were fed the high phenylalanine diet from 22nd day of age up to 3 months of age, and thereafter they were fed a normal diet for appropriate period (Rehabilitated PKU rats).Gain in body weight was clearly lowered in the PKU and Rehabilitated PKU rats (R-PKU rats), but the DNA content per cerebrum did not differ from that of the controls. The concentration of 5-hydroxytryptamine (5-HT) and 5-hydroxyindol acetic acid (5-HIAA) in the cerebrum decreased sig-nificantly in the PKU rats, while the R-PKU rats showed normal values. The activity of 2', 3'-cyclic nucleotide 3'-phosphohydrolase (CNPase) decreased sig-nificantly in the cerebrum of the PKU and R-PKU rats. Operant brightness discriminative learning ability of the PKU and R-PKU rats was found to be disturbed compared to that of the controls.It was suggested that the poor learning ability in the PKU rats was more closely related to the dysmyelination in the cerebrum than other neural elements such as DNA and monoamine contents.
- The Keio Journal of Medicineの論文
著者
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Tsukada Yasuzo
Department Of Physiology Keio University School Of Medicine
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Kohsaka Shinichi
Department Of Neurochemistry National Institute Of Neuroscience
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