Diabetes mellitus- and cooling-induced bladder contraction: an in vitro study
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概要
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The effects of diabetes mellitus during cooling on ACh- and KCl-induced responses were investigated in rat urinary bladder. Diabetes was induced in the rats by 50 mg/kg streptozotocin via an intraperitoneal injection. Rats’ body and bladder weights were measured. The isometric tension to ACh (10–9 – 3 × 10–4 M) and KCl (5–100 mM) in strips of urinary detrusor muscle of diabetic and non-diabetic rats, in organ baths at 37 and 28ºC were recorded. The body weights were significantly decreased and the bladder weights increased in STZ-induced diabetic group compared to the non-diabetic group. ACh and KCl caused concentration-dependent contractions of urinary bladders from non-diabetic and STZ-induced diabetic rats. During cooling, the sensitivity and the maximal response were significantly higher than those during 37ºC, both in non-diabetic and diabetic preparations. Cooling of detrusor muscle preparations induces a graded contraction inversely proportional to the temperature in diabetic rats. It may be assumed that the cooling response involves the same mechanisms in the diabetic and non-diabetic animals.
著者
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Kalkan Serpil
Department of Histology and Embriology, Faculty of Meram Medicine, University of Selçuk
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Atalık Kismet
Department of Pharmacology, Faculty of Meram Medicine, University of Selçuk
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Okudan Nilsel
Department of Physiology, Faculty of Meram Medicine, University of Selçuk
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Gokbel Hakki
Department of Physiology, Faculty of Meram Medicine, University of Selçuk
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Cuce Gokhan
Department of Histology and Embriology, Faculty of Meram Medicine, University of Selçuk
関連論文
- Diabetes mellitus- and cooling-induced bladder contraction: an in vitro study
- Diabetes mellitus- and cooling-induced bladder contraction: an in vitro study