Toxicity and Distribution of a new Nitrofuran Derivative Nifurprazine(HB-115)in Eels

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The toxicity and distribution of 1-(5-nitro-2-furyl)-2-(6-amino-3-pyridazyl)-ethylene hydrochloride (nifurprazine hydrochloride, HB-115·HCl) were investigated in eels. The results were as follows.<BR>1. Single oral administration of HB-115·HCl, mixed in feed, at a dose of 267mg/kg did not show any signs of toxicity in eels. Administration of HB-115·HCl at a dose of 52.2mg/kg/day for 7 days caused no death.<BR>2. Eel frys were immersed in fresh-water containing various concentrations of HB-115HCl at 15°C for 2 days, and then transferred into water without HB-115·HCl. Mortalities were checked 3 days later. TLm values for eel frys caught in Japan and France were 5.5 and 6.1mcg/ml, respectively. When eel frys were kept in the water containing HB-115HCl at such a high level as 100mcg/ml for 30 minutes at 15°C, they did not show any toxic signs.<BR>3.The levels of HB-115·HCl in serum and various organs of eels was determined bysuperposition method using E.coli as an indicater organism. After bathing in fresh-water containing 40mcg/ml of HB-115·HCl for 30 minutes at 25°C, eels were transferred into water without HB-115·HCl and tissue levels were determined 1/4, 1/2, 1, 2, 4, 8, 24 hours later. HB-115·HCl was detected in serum and skin. Their levels descended rather rapidly with the lapse of time. HB-115·HCl was not detected in liver, kidney and muscle.<BR>When eels were bathed in the water containing 2mcg/ml of HB-115·HCl for 24 hours at 25°C, HB-115·HCl was detected in serum and skin immediately thereafter, but not in liver, kidney and muscle.
日本魚病学会の論文

Toxicity and Distribution of a new Nitrofuran Derivative Nifurprazine(HB-115)in Eels

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