The Pattern of Burkitt's Lymphoma in Malaysian Patients
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概要
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Endemic and sporadic Burkitts lymphoma differ in site and age of presentation, and Epstein-Barr virus (EBV) association. This study aimed to describe the clinical presentation, EBV association and p53 expression of Burkitts lymphoma in 59 Malaysian patients. Expression of Bcl-2, retinoblastoma and Ki67 proteins was also investigated. EBV was detected by EBER in situ hybridization. Expression of p53, Bcl-2, pRb and Ki67 proteins was detected by immunohistochemical staining. Polymerase chain reaction was employed for EBV subtyping and detection of translocation t (14; 18). The male to female ratio was 3.9: 1. The most common age group was children younger than 15 years (72.9%), with a mean of 15.8y. The disease is more common in ethnic Chinese. EBV association is 33.3% and all were infected with type-A virus. Expressions of p53, Bcl-2, pRb and Ki67 proteins were detected in 42/49 (85.7%), 9/54 (16.7%), 47/51 (92.2%) and 35/39 (89.7%) of the biopsies, respectively. Translocation t (14; 18) was not detected in cases expressing the Bcl-2 protein. Clinical presentation and EBV association of Burkitts lymphoma in Malaysian patients corresponds with that of sporadic Burkitts lymphoma. This study also reveals that a substantial proportion of cases express high levels of p53 and retinoblastoma proteins, in contrast to the Bcl-2 protein.
- 日本リンパ網内系学会の論文
- 2002-10-01
著者
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Lin Hai-peng
Department Of Pediatrics Faculty Of Medicine University Of Malaya
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Kim Lian-hua
Department Of Pathology University Of Malaya Medical Center
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Kim Lian-hua
Department Of Pathology Faculty Of Medicine University Of Malaya
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Peh Suat-cheng
Department Of Pathology University Of Malaya Medical Center
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Peh Suat-cheng
Department Of Pathology Faculty Of Medicine University Malaya
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Tai Yan-chin
Department Of Pathology University Of Malaya Medical Center
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Tai Yan-chin
Department Of Pathology Faculty Of Medicine University Of Malaya
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JAIRAMAN Shaminie
Department of Pathology, University of Malaya
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GAN Shiaw-Sze
Department of Internal Medicine, University of Malaya
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Gan Shiaw-sze
Department Of Internal Medicine University Of Malaya
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Jairaman Shaminie
Department Of Pathology University Of Malaya
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