G-CSF does not Stimulate Leukemic Stem Cells in Vivo.

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概要

• 論文の詳細を見る

• The effect of G-CSF on leukemic stem cells, which can support the long-term proliferation of leukemic cells in vivo, needs to be clarified to confirm the long-term safety of clinical use of G-CSF. When we examined the effect of G-CSF on leukemic stem cells in NOD/SCID mice using a transplantation assay, the engraftment of leukemic cells derived from 8 AML cases was neither supported by G-CSF alone, nor enhanced by G-CSF plus GM-CSF, IL-3 and SCF. These findings suggest that G-CSF was not able to stimulate leukemic stem cells into maintaining the long-term proliferation of leukemic cells in vivo.

• 日本リンパ網内系学会の論文

著者

• ASANO Yoshinobu

  Chihaya Hospital

• KINUKAWA Naoko

  Dept. of Medical Information Science, Kyushu University

• NIHO Yoshiyuki

  Chihaya Hospital

• Shimoda Kazuya

  The First Department Of Internal Medicine Faculty Of Medicine Kyushu University

• GONDO Hisashi

  The First Department of Internal Medicine, Faculty of Medicine, Kyushu University

• NUMATA Akihiko

  The First Department of Internal Medicine, Faculty of Medicine, Kyushu University

• Okamura Takashi

  The First Department Of Internal Medicine Faculty Of Medicine Kyusyu University

• Shimoda Kazuya

  The First Dept. of Internal Medicine, Kyushu University

• Takase Ken

  The First Dept. of Internal Medicine, Kyushu University

• Gondo Hisashi

  The First Dept. of Internal Medicine, Kyushu University

• Numata Akihiko

  The First Dept. of Internal Medicine, Kyushu University

• Okamura Takashi

  The First Dept. of Internal Medicine, Kyushu University

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