Studies on cell-mediated immunity and prognosis of patients with digestive canal cancers treated with OK-432

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In order to study the cell-mediated immunity in patients with cancer of the gastrointestinaltract, peripheral mononuclear cells of patients treated generally of locally with OK-432 weretested for T-cells, B-cells, natural killing (NK) activity, antibody dependent cell-mediatedcytotoxic (ADCC) activity, interleukin 2 (IL-2) production with determination of serumlevels of interferon (IFN).The results were as follows: (1) In 32 patients with systenic treatment by OK-432, NKactivity and serum IFN levels showed a significant (p<0.05). (2) In 22 patients treated withlocal injection of OK-432, NK and ADCC activity increased significantly (p<0.01). In 2cases of these patients, tumor mass regressed with disappearance of malignant cells inthe repeated biopsy specimens.(3) In 18 patients treated without OK-432, NK activity ADCC activity and IL-2 productionshowed significant decrease (p<0.05).(4) In patients with better prognosis, T-cell percent and NK activity were significantlyhigher than those in patients with poorer prognosis.