Ovariectomy Decreases Luteinizing Hormone-Releasing Hormone-Degrading Activities in the Anterior Pituitary in Female Mice
スポンサーリンク
概要
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Changes in the luteinizing hormone-releasing hormone-degrading activities (LHRH-DA) in the anterior pituitary and the hypothalamus after ovariectomy (OVX) were examined in mice. Mice were decapitated at 1000 h on diestrus day 1 (D1) or on day 7, 14 and 21 after OVX. Another group of mice was also killed at 1000, 1200, 1500 and 1700 h on D1 or on day 7 after OVX to determine the change in LHRH-DA during the day. Trunk blood, the anterior pituitary and hypothalamic tissue were collected. LHRH-DA were determined by incubating the exogenous LHRH with tissue extracts at 37C for 30 min. The changes of LHRH-DA in the anterior pituitary were inversely correlated with those of LH secretion: LHRH-DA decreased after OVX when plasma LH levels increased, but did not change when plasma LH levels were kept at a stable level throughout the day on D1 or day 7 after OVX. The present results suggest that the LHRH-DA in the anterior pituitary is involved in its hypersensitivity to the LHRH stimulation after OVX.
- 日本繁殖生物学会の論文
著者
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OKUDA Kiyoshi
Division of Animal Science and Technology, Faculty of Agriculture, Okayama University, Okayama 700,
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Okuda Kiyoshi
Division Of Animal Science And Technology Faculty Of Agriculture Okayama University
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NAGATANI Shoji
Division of Animal Science, Faculty of Agriculture, Okayama University
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YUHARA Masataka
Division of Animal Science, Faculty of Agriculture, Okayama University
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OKUDA Kiyoshi
Division of Animal Science, Faculty of Agriculture, Okayama University
関連論文
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- Epidermal Growth Factor and Its Receptor in Bovine Corpus Luteum during the Estrous Cycle
- Ovariectomy Decreases Luteinizing Hormone-Releasing Hormone-Degrading Activities in the Anterior Pituitary in Female Mice
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