NEUROPHARMACOLOGICAL STUDIES ON A NEW SERIES OF ERGOT ALKALOIDS:ELYMOCLAVINE AS A POTENT ANALEPTIC ON RESERPINE-SEDATION

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Sedation induced by reserpine has been considered "true" sedation because anesthesia or loss of the righting reflex is never produced by reserpine even in very large doses [Berger, 1957 (1)]. Reserpine might be a serotonin liberator and its central actions are attributed to the liberated serotonin [Brodie, <I>et al</I>. 1957 (2)]. On the other hand, lysergic acid diethylamide (LSD), a specific psychotomimetic agent, is well known as a potent inhibitor of serotonin [Gaddum, 1953 (3)]. Actually, LSD not only blocks the reserpine-induced sedation, but also inhibits the potentiating effect of reserpine on barbiturate hypnosis in mice [Brown, 1957 (4)]. Burton (1957) (5) found that both LSD and amphetamine have a selective analeptic action on the reserpine-sedation among various kinds of agents including central stimulants or autonomic blocking agents. According to Teschler and Cerletti (1957) (6), reserpine is rather a potentiator of the central stimulatory action of LSD.<BR>Kumagai and Yui (1950) (7) reported on the general pharmacology of agroclavine and dihydroagroclavine which Abe and his collaborators (1951) (8) had newly isolated from the saprophytic culture of a certain ergot fungus. Agroclavine caused some characteristic symptoms with central excitation, while dihydroagroclavine drowsiness as a sign of central depression. Recenty, Abe (1956) (9) has obtained a lot of derivatives of ergot alkaloids, the so-called "agroclavine-type" compounds (illustrated in Table 1), by means of cultural and chemical procedures.<BR>This paper is concerned with the central action of these compounds, with special reference to their reserpine-antagonism.
公益社団法人日本薬理学会の論文

NEUROPHARMACOLOGICAL STUDIES ON A NEW SERIES OF ERGOT ALKALOIDS:ELYMOCLAVINE AS A POTENT ANALEPTIC ON RESERPINE-SEDATION

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