Protective Effect of Rebamipide against Hydrogen Peroxide-Induced Hemorrhagic Mucosal Lesions in Rat Stomach.

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概要

• 論文の詳細を見る

• Intragastric administration of 6% H<SUB>2</SUB>O<SUB>2</SUB> induces gastric mucosal hemorrhagic lesions in rats. Intraperitoneal administration of rebamipide at 10 to 100 mg/kg dose-dependently prevented the H<SUB>2</SUB>O<SUB>2</SUB>-induced mucosal lesions. The fact that cimetidine, ranitidine and omeprazole could not prevent the gastric mucosa from developing H<SUB>2</SUB>O<SUB>2</SUB>-induced lesions indicates that acid secretion might not be the main cause of these lesions. The protective effect of rebamipide was partially reduced by indomethacin and completely blocked by diethyl maleate, a glutathione depressor. Gastric mucosal glutathione level and glutathione peroxidase and superoxide dismutase (SOD) activities were significantly decreased by 6% H<SUB>2</SUB>O<SUB>2</SUB> instillation. Rebamipide at 100 mg/kg significantly inhibited the decreases in gastric mucosal glutathione level and SOD activity. These results suggest that H<SUB>2</SUB>O<SUB>2</SUB>-induced gastric mucosal lesions might partially involve a decrease in defense activities against reactive oxygen species and that the protective effect of rebamipide might be related to its ability to improve oxidative stress in gastric mucosa.

• 公益社団法人 日本薬理学会の論文

著者

• Yamasaki Katsuya

  Department of Pharmacology and Experimental Therapeutics, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

• Sakurai Kazushi

  Department of Pharmacology and Experimental Therapeutics, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

関連論文

• Direct evidence for central action of PCPGABA to stimulate gastric acid secretion by intracisternal injection.
• Protective Effect of Rebamipide against Hydrogen Peroxide-Induced Hemorrhagic Mucosal Lesions in Rat Stomach.

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