Studies on the Antiinflammatory, Antipyretic and Analgesic Activities of Santonin.

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概要

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• Santonin, a sesquiterpene lactone, commonly found in the plants of the family <I>Compositae</I> was found to show significant antiinflammatory activity on acute inflammatory processes. The activity profile of santonin closely resembled that of a standard non-steroidal antiinflammatory drug, diclofenac sodium. It also showed a significant inhibitory effect on granuloma formation; however, this effect of santonin was less pronounced as compared to diclofenac sodium. Santonin caused a significant antipyretic effect in mice, which was found to be independent of the route of administration of the drug. It also increased the hot plate reaction time of treated mice, similar to morphine.

• 公益社団法人 日本薬理学会の論文

著者

• Miana Ghulam

  Department of Chemistry, College of Science, Gomal University

• Al-Harbi Mohammed

  Department of Pharmacology, King Saud University

• Qureshi Shoeb

  Quality Control and Research Laboratory, Experimental Animal Care Center, College of Pharmacy, King Saud University

• Ahmed Mohammad

  Quality Control and Research Laboratory, Experimental Animal Care Center, College of Pharmacy, King Saud University

• Raza Mohammad

  Department of Pharmacology, King Saud University

• Shah Arif

  Department of Chemistry, College of Science, Gomal University

関連論文

• Studies on the Antiinflammatory, Antipyretic and Analgesic Activities of Santonin.

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