Adenosine Induces Contractions in Suncus Ileum.

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概要

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• Purinoceptor-mediated responses were characterized in the ileum of <I>Suncus murinus</I>. Adenosine as well as adenosine 5''-triphosphate (ATP) contracted the ileum in a concentration-dependent manner. Contractile responses to transmural electrical stimulation were attenuated by adenosine only at high concentrations. Theophylline competitively blocked the adenosine-induced contraction. Atropine also inhibited the adenosine-induced contraction but in a non-competitive manner. The ATP-induced contraction was not affected by theophylline, atropine or α, β-methylene ATP. Indomethacin shifted the concentration-response curves for adenosine and ATP to the right. These results suggest that adenosine elicited contractions via direct stimulation of postsynaptic P<SUB>1</SUB>-purinoceptors and postsynaptic potentiation of the acetylcholine response. Suncus ileum will be a unique model for the analyses of purinoceptor-mediated responses.

• 公益社団法人 日本薬理学会の論文

著者

• MATSUKI Norio

  Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo

関連論文

• Adenosine Induces Contractions in Suncus Ileum.

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