Protection against .ALPHA.-Naphthylisothiocyanate-Induced Acute Cholestasis in Mice by a Novel Taurine Conjugate of Ursodeoxycholate (UR-906).

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概要

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• We investigated the effects of tauroursodeoxycholate (UR-906) and ursodeoxycholic acid (UDCA) on α-naphthylisothiocyanate (ANIT)-induced cholestasis in mice. UR-906 and UDCA were given intravenously 2 hr prior to and 2 hr after ANIT (80 mg/kg, p.o.) treatment. The animals were sacrificed 48 hr after ANIT administration, and serum markers of liver injury were examined. UR-906 prevented significant elevations in total bilirubin, bile acids and LDH. Furthermore, this drug reduced significant elevations in ALP and LAP. UDCA also prevented significant elevations in total bilirubin and LAP. These results indicate that UR-906 as well as UDCA has a beneficial effect against ANIT-induced cholestasis in mice.

• 公益社団法人 日本薬理学会の論文

著者

• Miyazawa Norio

  Pharmaceutical Institute Tohoku University

• Ishizaki Kaoru

  Pharmacological Research Laboratory, Research Laboratories, Tokyo Tanabe Co., Ltd.

• Kinbara Shigemasa

  Pharmacological Research Laboratory, Research Laboratories, Tokyo Tanabe Co., Ltd.

• Takeuchi Yoshishige

  Pharmacological Research Laboratory, Research Laboratories, Tokyo Tanabe Co., Ltd.

• Araki Tsutomu

  Pharmacological Research Laboratory, Research Laboratories, Tokyo Tanabe Co., Ltd.

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• Protection against .ALPHA.-Naphthylisothiocyanate-Induced Acute Cholestasis in Mice by a Novel Taurine Conjugate of Ursodeoxycholate (UR-906).

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