Effect of Systemic Anaphylaxis on the Hepatic Drug-Metabolizing System in Rats.

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概要

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• Rats were immunized by intraperitoneal injection of ovalbumin emulsified with Freund incomplete adjuvant, and then the effect of an intravenous challenge with ovalbumin on hepatic drug-metabolizing enzyme activities was examined. The cytochrome P-450 content and ethylmorphine N</I>-demethylase, benzphetamine N</I>-demethylase, arylhydrocarbon hydroxylase and 7-ethoxycoumarin O</I>-deethylase activities significantly decreased in rats treated with ovalbumin compared with control groups treated with saline, whereas there was no significant reduction in cytochrome b<SUB>5</SUB>, NADPH-cytochrome c reductase and NADH-cytochrome c reductase.

• 公益社団法人 日本薬理学会の論文

著者

• TAKAYANAGI Yoshio

  Department of Pharmacology and Toxicology, Cancer Research Institute, Tohoku College of Pharmacy

関連論文

• Effect of Systemic Anaphylaxis on the Hepatic Drug-Metabolizing System in Rats.

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