Improving Effects of FG-7080, a Serotonin Reuptake Inhibitor, on Scopolamine-Induced Performance Deficits of Memory Tasks in Rats.

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概要

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• A novel serotonin reuptake inhibitor, (-)<I>trans</I> 4-(4-fluorophenyl)-3-(4-methoxyphenoxy-methyl)piperidine hydrochloride (FG-7080), was investigated for its effects on scopolamine-induced impairments in memory tasks of rats. In the radial-arm maze task, FG-7080 (3 mg/kg, p.o.) improved the impaired performance. FG-7080 (1 mg/kg, p.o.) administered before the acquisition trial reduced the acquisition deficits in the passive avoidance task. Thus, the compound showed improving effects in the appetitive and aversive memory tasks. These findings suggest that FG-7080 may ameliorate the cognitive impairments caused by the cholinergic dysfunction.

• 公益社団法人 日本薬理学会の論文

著者

• Miura Naoyoshi

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd

• Tanaka Yoshiaki

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd

• Nakata Naoki

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.

• Miura Naoyoshi

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.

• Hiraga Yoshihiro

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.

• Ikeda Yugo

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.

• Ohata Hisayuki

  Institute of Psychology, University of Tsukuba

• Iwasaki Tsuneo

  Institute of Psychology, University of Tsukuba

• Tanaka Yoshiaki

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.

関連論文

• Decrease of Sexual Receptivity by Prolylendopeptidase Inhibitor in Female Rats
• Improving Effects of FG-7080, a Serotonin Reuptake Inhibitor, on Scopolamine-Induced Performance Deficits of Memory Tasks in Rats.
• Functional Dissociation of Striatal and Hippocampal Cholinergic Systems in Egocentric and Allocentric Localization : Effect of Overtraining

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