Involvement of .ALPHA.1- but Not .ALPHA.2-Adrenergic Systems in the Antagonizing Effect of Paeoniflorin on Scopolamine-Induced Deficit in Radial Maze Performance in Rats.

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概要

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• Paeoniflorin, a major constituent of peony root (1 mg/kg, p.o.), attenuated scopolamine-induced deficit in radial maze performance. Both prazosin (0.5 mg/kg, i.p.) and yohimbine (0.3 mg/kg, i.p.) neither impaired radial maze performance by itself nor augmented the scopolamine-induced performance deficit. Prazosin significantly blocked the antagonizing effect of paeoniflorin on the scopolamine deficit, whereas yohimbine did not affect the paeoniflorin effect. These data suggest that the α<SUB>1</SUB>-adrenergic but not α<SUB>2</SUB>-adrenergic systems are involved in the antagonizing effect of paeoniflorin on the scopolamine deficit in radial maze performance in rats.

• 公益社団法人 日本薬理学会の論文

著者

• Matsumoto Kinzo

  Section of Pharmacology, Research Institute for Wakan-Yaku, Department of Medical Resources, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

関連論文

• Involvement of .ALPHA.1- but Not .ALPHA.2-Adrenergic Systems in the Antagonizing Effect of Paeoniflorin on Scopolamine-Induced Deficit in Radial Maze Performance in Rats.

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