Antisecretory and Antiulcer Effects of Ebselen, a Seleno-Organic Compound, in Rats.

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概要

• 論文の詳細を見る

• The effects of ebselen (2-phenyl-1, 2-benzisoselenazol-3(2<I>H</I>)-on), a metal-containing organic compound, on gastric secretion and gastric ulceration were examined in rats. Intraduodenal ebselen (30 to 300 mg/kg)significantly and dose-dependently inhibited gastric secretion in pylorus-ligated rats. Both aspirin and water-immersion restraint stress-induced ulcers were significantly prevented by oral administration of ebselen at doses equivalent to the antisecretory doses. These results indicate that the antisecretory effect of ebselen underlies its antiulcer effect in these models.

• 公益社団法人 日本薬理学会の論文

著者

• Tabuchi Yoshiaki

  Exploratory Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.

• Kurebayashi Yoichi

  Exploratory Research Laboratories III, Daiichi Pharmaceutical Co., Ltd.

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• Antisecretory and Antiulcer Effects of Ebselen, a Seleno-Organic Compound, in Rats.
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