Involvement of Nitric Oxide in Endothelium-Dependent, Phasic Relaxation Caused by Histamine in Monkey Cerebral Arteries.

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概要

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• Monkey cerebral artery strips partially contracted with prostaglandin F<SUB>2α</SUB> responded to histamine with biphasic patterns of relaxation. The delayed and sustained relaxation was suppressed by cimetidine, whereas the phasic response was abolished by treatment with chlorpheniramine and <I>N<SUP>G</SUP></I>-nitro-L-arginine (L-NA), a nitric oxide (NO) synthase inhibitor. The inhibition by L-NA was reversed by L-arginine. D-NA was without effect. Endothelium denudation abolished the phasic relaxation. We hypothesized that endothelium-dependent, phasic relaxations caused by histamine are mediated by NO that is released by H<SUB>1</SUB>-receptor stimulation, whereas the sustained relaxation is associated with the activation of H<SUB>2</SUB>-receptors in the smooth muscle of monkey cerebral arteries.

• 公益社団法人 日本薬理学会の論文

著者

• Ayajiki Kazuhide

  Department of Pharmacology, Shiga University of Medical Sciences

関連論文

• Involvement of Nitric Oxide in Endothelium-Dependent, Phasic Relaxation Caused by Histamine in Monkey Cerebral Arteries.

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