Effects of Nitric Oxide Synthase Inhibitors on Gastric Alkaline Secretion in Rats.

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概要

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• The effects of <I>N<SUP>G</SUP></I>-nitro-L-arginine methyl ester (L-NAME), the nitric oxide (NO) synthase inhibitor, on gastric HCO<SUB>3</SUB><SUP>-</SUP> secretion were examined in anesthetized rats. Intravenous administration of L-NAME (1, 2.5, 5 mg/kg) increased HCO<SUB>3</SUB><SUP>-</SUP> secretion in a dose-related manner. This effect of L-NAME was mimicked by <I>N<SUP>G</SUP></I>-mono-methyl-L-arginine (50 mg/kg, i.v.) and was antagonized significantly by concurrent administration of L-arginine but not D-arginine (200 mg/kg, i.v.). These results indicate that gastric HCO<SUB>3</SUB><SUP>-</SUP> secretion is stimulated by inhibition of NO biosynthesis.

• 公益社団法人 日本薬理学会の論文

著者

• Sugawara Hiromi

  Department of Applied Pharmacology, Kyoto Pharmaceutical University

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• Effects of Nitric Oxide Synthase Inhibitors on Gastric Alkaline Secretion in Rats.

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