Effects of Isolation Housing and Timing of Drug Administration on Theophylline Kinetics in Mice.

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概要

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• ICR mice were grouped according to 1) housing environment: individual (I) or aggregated (A) and 2) timing of drug administration: midlight (L) or middark (D), i.e. I-L, I-D, A-L, A-D groups. Theophylline was orally administered at midlight or middark. The results showed that both social environment and timing of drug administration exerted significant influence on the pharmacokinetics of theophylline. These data may suggest the importance of considering many non-drug factors in toxicological studies with experimental animals.

• 公益社団法人 日本薬理学会の論文

著者

• Nakano Shigeyuki

  Department of Clinical Pharmacology and Therapeutics, Oita Medical University

関連論文

• Chronotoxicity and Chronopharmacokinetics of Methotrexate in Mice: Modification by Feeding Schedule.
• Effects of Isolation Housing and Timing of Drug Administration on Theophylline Kinetics in Mice.

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