Hypolipidemic Effect of Ethyl <I>all-cis</I>-5, 8, 11, 14, 17-Icosapentaenoate (EPA-E) in Rats
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概要
- 論文の詳細を見る
We examined the effect of ethyl <I>all-cis</I>-5, 8, 11, 14, 17-icosapentaenoate (EPA-E) with high purity on circulating lipids in rats under several experimental conditions. In normolipidemic rats, EPA-E decreased the lipids in a dose-dependent manner. Clofibrate (100 mg/kg/day) was more potent in lowering the lipids than EPA-E (1000 mg/kg/day). In high cholesterol diet-fed rats, EPA-E (300 mg/kg/day) decreased the total cholesterol. However, clofibrate (300 mg/kg/day) had little effect on the total cholesterol. In hypertriglycemic rats induced by corn oil, EPA-E (300 mg/kg/day) or clofibrate (100 mg/kg/day) reduced the rise of triglycerides. EPA-E (300 mg/kg/day), clinofibrate (100 mg/kg/day) or clofibrate (300 mg/kg/day) caused a significant reduction in the lipids induced by the injection of Triton WR-1339. Furthermore, EPA-E (300 mg/kg/day) or clinofibrate (100 mg/kg/day) decreased the elevation of lipids produced by feeding the rats a casein-rich diet. These results show that EPA-E possesses potent inhibitory activity on experimental hyperlipidemia induced either exogenously or endogenously.
著者
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SAITO Yasushi
The Second Department of Internal Medicine, School of Medicine, Chiba University
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Yano Takashi
Fuji Central Research Lab. Mochida Pharmaceutical Co. Ltd.
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Mizota Masahiro
Fuji Central Research Laboratory Mochida Pharmaceutical Co. Ltd. 722
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Saito Yasushi
The Second Department Of Internal Medicine Chiba University School Of Medicine
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Masada Atsuhiro
Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.
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Mizuguchi Kiyoshi
Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.
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Kojima Masahiro
Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.
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Tanaka Yasuo
Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.
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Ishibashi Masaaki
Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.
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Sato Masami
Toxicology Laboratory, Mochida Pharmaceutical Co., Ltd.
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Fukutake Katsuhiko
Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.
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Yano Takashi
Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.
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