Recombinant Human Tumor Necrosis Factor-.BETA. Entrapped in Liposomes Formed by a Modification of the Dehydration-Rehydration Method Retains Potent Cytotoxic Activity on L929 Cells In Vitro.

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概要

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• Recombinant human tumor necrosis factor-β (rhTNF-β) may be encapsulated with high efficiency in phosphatidylcholine and distearoylphosphatidylcholine liposomes, with entrapment values of 93.4% and 92.3%, respectively, by first entrapping the substance in multilamellar vesicles using a high solute-to-phospholipid ratio followed by freeze-drying and then rehydration. The entrapped cytokine retains potent cytotoxic activity on L929 cells in vitro, causing 100% cytotoxicity, equal to that of free rhTNF-β at a concentration of about 5 × 10<SUP>-8</SUP> g/ml.

• 公益社団法人 日本薬理学会の論文

著者

• Goh Cynthia

  Institute of Molecular and Cell Biology, National University of Singapore

• Tan Lloyd

  Department of Pharmacology, Faculty of Medicine, National University of Singapore

• Porter Alan

  Institute of Molecular and Cell Biology, National University of Singapore

関連論文

• Recombinant Human Tumor Necrosis Factor-.BETA. Entrapped in Liposomes Formed by a Modification of the Dehydration-Rehydration Method Retains Potent Cytotoxic Activity on L929 Cells In Vitro.

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