Cholecystokinin Protects Cholinergic Neurons against Basal Forebrain Lesion

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概要

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• Alzheimers Disease (AD) patients have a severe degeneration of cholinergic neurons in their cerebral cortices. Basal forebrain (BF)-lesioned rat is used as a model animal of a cholinergic deficit in the cerebral cortex. Cholinergic markers were decreased in the cerebral cortex of BF-lesioned rats. Intracerebroventricular continuous infusion of cholecystokinin octapeptide (CCK8) following BF lesion obviously preserved these cholinergic markers. These results suggest that CCK8 prevents the degeneration of cholinergic neurons in the cerebral cortex following BF lesion.

著者

• Kubota Kazuhiko

  Research Institute For Biosciences Science University Of Tokyo

• Takahashi Masanori

  Research Institute for Biosciences, Science University of Tokyo

• Sugaya Kiminobu

  Research Institute for Biosciences, Science University of Tokyo

関連論文

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• Cholecystokinin Protects Cholinergic Neurons against Basal Forebrain Lesion

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