FATTY ACID COMPOSITION OF CHOLESTERYL ESTERS IN CHOLESTEROL-FED RABBITS TREATED WITH LIPID-LOWERING AGENT (ETHYL 2-(<I>p</I>-CHLOROPHENOXY) ISOBUTYRATE)

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概要

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• Regression mechanism of Ethyl 2-(<I>p</I>-chlorophenoxy) isobutyrate (CPIB) in the arterial wall was studied for elucidation in terms of fatty acid-compositional change in cholesterol-fed rabbits. The following evidence was obtained: (1) The amount of cholesterol and cholesteryl ester in the atheromatous aorta were reduced after CPIB treatment. (2) CPIB resulted in a significant increase in the ratio of linoleate to oleate in both the arterial wall and serum after withdrawal of the cholesterol diet. It is suggested that there is a preferential hydrolysis of linoleate-rich cholesteryl ester in both the arterial wall and the serum.

• 社団法人 日本薬理学会の論文

著者

• SATO Masao

  Kotobuki Seiyaku

• TAKANO Tatsuya

  Faculty of Pharmaceutical Sciences, Teikyo University

関連論文

• FATTY ACID COMPOSITION OF CHOLESTERYL ESTERS IN CHOLESTEROL-FED RABBITS TREATED WITH LIPID-LOWERING AGENT (ETHYL 2-(p-CHLOROPHENOXY) ISOBUTYRATE)

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