HISTAMINE-INDUCED ACTH SECRETION AND INHIBITORY EFFECT OF ANTIHISTAMINIC DRUGS

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概要

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• Concentration of adrenocorticotropic hormone (ACTH) in the serum increased and reached the maximum level 10 min after the injection of histamine (dihydrochloride, 0.5 or 1 mg/100 g) i.p. into rats. The maximum concentration of ACTH in the serum was dependent on the dose of histamine. The ACTH concentration then decreased and was close to the normal level 30 to 60 min after the injection. The ACTH secretion induced by histamine (0.5 mg/100 g) was inhibited completely by the pretreatment with the antagonists of H<SUB>1</SUB>-receptor, diphenhydramine (hydrochloride, 0.2-0.5 mg/100 g), promethazine (hydrochloride, 0.1-0.2 mg/100 g) and d-chlorpheniramine (maleate, 0.02-0.05 mg/ 100 g). The antagonist of H<SUB>2</SUB>-receptor, metiamide (2-4 mg/100 g) inhibited the ACTH secretion significantly but not completely. These results suggest that H<SUB>1</SUB>-receptor plays a major role in the histamine-induced ACTH secretion, although H<SUB>2</SUB>-receptor is also involved in this ACTH secretion.

• 社団法人 日本薬理学会の論文

著者

• MORITA YOSHIKO

  Division of Bio-Function Research, Biomedical Research Laboratories, Jikei University School of Medicine

• KOYAMA KUNIKO

  Division of Bio-Function Research, Biomedical Research Laboratories, Jikei University School of Medicine

関連論文

• ACTH Bioassay Using Isolated Adrenal Cells and Its Application to Determination of Serum and Pituitary ACTH Levels in Morphine-Injected Rats
• HISTAMINE-INDUCED ACTH SECRETION AND INHIBITORY EFFECT OF ANTIHISTAMINIC DRUGS
• Action of partially purified ACTH-potentiating substance from rat serum on isolated rat adrenal cells.

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