STUDIES ON COMBINATION DOSING (III) ASPIRIN AND ETHENZAMIDE

スポンサーリンク

概要

• 論文の詳細を見る

• In our studies with drug combinations, we searched for mixtures which would enhance the effectiveness of the related active substances. Ethenzamide was found to possess a specific suppressive effect on the gastric damage induced by aspirin. Such effect could not be demonstrated in analgesic agents such as salicylamide, bucetin, acetaminophen and phenacetin. The combination of aspirin with ethenzamide had a potentiating effect on analgesic activity and reduced motor incoordination and loss of righting reflex. We calculated the safety margins of various ratios of combinations and concluded that the best was aspirin and ethenzamide at a ratio of 2:3.

• 社団法人 日本薬理学会の論文

著者

• KAWANO Osamu

  Biological Section, Research Laboratory, Grelan Pharmaceutical Co., Ltd.

• SAWABE Takashi

  Biological Section, Research Laboratory, Grelan Pharmaceutical Co., Ltd.

• MISAKI Noriyuki

  Biological Section, Research Laboratory, Grelan Pharmaceutical Co., Ltd.

• FUKAWA Kazunaga

  Biological Section, Research Laboratory, Grelan Pharmaceutical Co., Ltd.

• Fukawa Kazunaga

  Biological Research Section Research And Development Of Grelan Pharmaceutical Co. Ltd.

関連論文

• STUDIES ON COMBINATION DOSING (III) ASPIRIN AND ETHENZAMIDE
• Myocarditis Induced by Sympathomimetic Amines (I)
• Experimental studies on gastric ulcer (4). Sequential observation and evaluation of gastric ulcers by endoscope in the rat.

スポンサーリンク