RAT LIVER ALDEHYDE DEHYDROGENASES: STRAIN DIFFERENCES IN THE RESPONSE OF THE ENZYMES TO PHENOBARBITAL TREATMENT
スポンサーリンク
概要
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The effect of phenobarbital on activities of aldehyde dehydrogenascs in the subcellular fractions was studied <I>in vivo</I> in rats of three strains. Regarding the responses of the mitochondrial and microsomal enzymes to phenobarbital treatment no difference among the strains was observed. Regarding the responses of the supernatant enzyme remarkable strain differences were observed. In rats of the Long-Evans strain the high Km-enzyme activity increased as much as 15-fold above control levels by phenobarbital treatment. By contrast, in rats of the Wistar strain the high Kmenzyme activity was unchanged in all rats by treatment with phenobarbital. In rats of the Sprague-Dawley strain the high Km-enzyme activity remained unchanged in 52 % of all rats treated with phenobarbital and was increased approximately 4-fold over control levels in 48 % of treated rats.
- 社団法人 日本薬理学会の論文
著者
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SHIOHARA Eiko
Department of Pharmacology, Faculty of Medicine, Shinshu University
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NAKANISHI Suehiro
Department of Pharmacology, Faculty of Medicine, Shinshu University
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Tsukada Miyoko
Department Of Pharmacology Shinshu University School Of Medicine
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