SOME PHARMACOLOGICAL STUDIES ON THE RENAL CARBONIC ANHYDRASE ACTIVITY AND ELECTROLYTES EXCRETION IN THE RAT
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Reabsorption of the sodium ion at the renal tubules is the main mechanism for maintaining appropriate water content of the body, and it is finely controlled by vasopressin and pituitary-adrenal hormones. Also, the kidney contains an appreciable amount of carbonic anhydrase which catalyzes exchange of H<SUP>+</SUP> with Na<SUP>+</SUP> in the tubules, and diamox, the potent inhibitor of this enzyme, is used as diuretic. This makes it interesting to study on possible regulatory function of vasopressin and pituitary-adrenal system on the carbonic anhydrase activity. Here will be reported our results of experiments on effect of desoxycorticosterone and alrenalectomy on the enzyme activity and diuresis.<BR>As substances impeding renal excretion of other drugs competitively, there are caronamide and benemid. They are used clinically as potentiators of penicillin and other drugs. SKF No. 525-A is a recently developed potentiator of mainly centrally acting drugs. They have been also studied as for their action on renal carbonic anhydrase and electrolyte excretion.
- 公益社団法人 日本薬理学会の論文
公益社団法人 日本薬理学会 | 論文
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