EFFECTS OF TIOPRONIN ON EXCRETION AND DISTRIBUTION OF 203Hg-LABELED MERCURY COMPOUNDS IN MICE

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Effects of repeated doses of tiopronin [N-(2-mercaptopropionyl)glycine] on elimination of 203Hg were determined by means of whole body counting after intravenous injection of 203Hg-methylmercuric chloride (Me 203HgCl), phenylmercuric acetate (Ph 203HgAc) or mercuric chloride (203HgCl2) into mice. The tissue distribution of 203Hg-mercury compounds was also observed, using a autoradiographic technique, and the effects of tiopronin were compared with those of 2, 3-dimercaptopropanol (BAL). Subcutaneous administrations of tiopronin stimulated excretion of radioelements from the whole body of mice given Me 203HgCl, the biological half-life of Me 203HgCl being shortened from 6.5 to 2.9 days. Autoradiographic studies showed that the radioactivities after Me 203HgCl injection were less in all organs in the tiopronintreated mice than in the controls after a temporary rise of radioactivities in the blood and secretory glands. The excretion of 203Hg from the mice given Ph 203HgAc or 203HgCl2 was also stimulated by tiopronin treatment, but the stimulation was much less than when the mice had been given Me 203HgCl. Repeated administrations of BAL remarkably increased the excretion of radioelement in the mice given Ph 203HgAc or 203HgCl2 but not Me 203HgCl. However, autoradiograms demonstrated that BAL enhanced accumulation of these compounds in the nervous system and muscle compared tic ith the control after injection of three different types of mercury compounds.
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EFFECTS OF TIOPRONIN ON EXCRETION AND DISTRIBUTION OF <SUP>203</SUP>Hg-LABELED MERCURY COMPOUNDS IN MICE

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