STUDIES ON THE MODE OF ANTAGONISM BETWEEN ADRENERGIC β-MIMETICS AND β-BLOCKING AGENTS (III) FUNCTIONAL ANTAGONISM BETWEEN β-MIMETICS AND SPASMOGENS

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概要

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• New equations which can explain the following characteristic phenomena in the functional antagonism between isoproterenol (ISO) and spasmogens in guinea-pig trachea are proposed: (1) The amplitude of relaxation of the muscle induced by ISO varied depending on the concentration of a spasmogen used (histamine or carbachol). (2) The dose-response curves for the relaxation by ISO shifted to the right in a parallel manner as the concentration of the spasmogen increased, and became stationary at higher concentrations of the spasmogen. (3) The slope of the dose-response curve became steeper with increasing concentrations of the spasmogen. When the saturable uptake process of ISO was taken into consideration, a satisfactory parallel was seen between the theoretical dose-response curves and the present experimental results.

• 社団法人 日本薬理学会の論文

著者

• OHASHI Motoaki

  Pharmacological Research Laboratory Tanabe Seiyaku Co., Ltd.

関連論文

• STUDIES ON THE MODE OF ANTAGONISM BETWEEN ADRENERGIC β-MIMETICS AND β-BLOCKING AGENTS (IV) INFLUENCE OF FUNCTIONAL ANTAGONISM BY SPASMOGENS
• STUDIES ON THE MODE OF ANTAGONISM BETWEEN ADRENERGIC β-MIMETICS AND β-BLOCKING AGENTS (III) FUNCTIONAL ANTAGONISM BETWEEN β-MIMETICS AND SPASMOGENS
• STUDIES ON THE MODE OF ANTAGONISM BETWEEN ADRENERGIC β-MIMETICS AND β-BLOCKING AGENTS (II) : ANALYSIS BY THE UPTAKE SATURATION MODEL
• STUDIES ON MODE OF ANTAGONISM BETWEEN ADRENERGIC β-MIMETICS AND β-BLOCKING AGENTS (I). β-BLOCKING ACTION OF MESCALINE AND ITS DERIVATIVES
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