ALLOMETRIC METHOD FOR THE LONG TERM OBSERVATION OF ADJUVANT ARTHRITIS IN RATS

スポンサーリンク

概要

• 論文の詳細を見る

• An allometric method for estimating the volume change in inflamed paw of rats is described. The technique is effective and advantageous for long term observation of adjuvant arthritis which lacks a suitable reference criterion due to the simultaneous swelling of the control paw. In the present method, the inflammatory intensity (IF) of paw edema is estimated by means of the formula: IF(%)={2V<SUB>t</SUB>/cX<SUP>d</SUP>(I÷W<SUB>t</SUB>/aX<SUP>b</SUP>)-I}×100 where V<SUB>t</SUB> is the paw volume, W<SUB>t</SUB> is the body weight and X is the tail length of the inflamed rat. The constants a, b, c and d are obtained from the normal rats using the relative growth law, W=aX<SUP>b</SUP> and V cX<SUP>d</SUP> (where W is the body weight, V is the paw volume and X is the tail length).

• 社団法人 日本薬理学会の論文

著者

• SATO NORIMITSU

  Department of Comparative Endocrinology Institute of Endocrinology, Gunma University

• TOMISAWA Shogo

  Department of Pharmacology, Research Laboratories, Chugai Pharmaceutical Co., Ltd.

関連論文

• UPTAKE OF RADIOACTIVE LEUCINE AND URIDINE BY THE CAUDAL NEUROSECRETORY CELL OF THE LOACH (MISGURNUS ANGUILLICAUDATUS)
• PREVENTIVE AND CURATIVE EFFECTS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS ON EXPERIMENTAL PERITONEAL INFLAMMATION IN MICE
• ALLOMETRIC METHOD FOR THE LONG TERM OBSERVATION OF ADJUVANT ARTHRITIS IN RATS

スポンサーリンク