EFFECT OF “DRUGS FOR LIVER DISEASE” ON HEPATOTOXIC ACTION OF CARBON TETRACHLORIDE : II. EFFECT OF PROTOPORPHYRIN AND PHOSPHORYLCHOLINE ON MICROSOMAL DRUG-METABOLIZING ENZYME ACTIVITIES AND THE COMPONENTS IN INJURED LIVER

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概要

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• The effect of “drugs for liver disease”, protoporphyrin (PP) and phosphorylcholine (PC), on CC1<SUB>4</SUB>-induced liver injury was studied. Attention was given to the levels of microsomal drug-metabolizing enzyme and lipolytic enzyme activities and of some microsomal components such as phospholipid and peroxides. Administration of PP to CC1<SUB>4</SUB>-poisoned rats was found to increase the decreased microsomal drug-metabolizing enzyme activities, aminopyrine N-demethylase, aniline p-hydroxylase, cytochrome P-450 and b<SUB>5</SUB> and lipolytic enzyme activity in CC1<SUB>4</SUB>-poisoned liver (12-20% increase as compared with those of the poisoned rats), and returned to control levels earlier than in CCl<SUB>4</SUB>-poisoned rats. Furthermore, administration of PP to CC1<SUB>4</SUB>-poisoned rats caused a decrease in the lipid peroxidation. A single dose of PP to normal rats was shown to increase these parameters, to a small extent. One of the mechanisms may be attributed to the fact that PP increases the biosynthesis of the hemoproteins by means of the incorporation of PP into the pigments and protects the membranes from lipid peroxides and the free radicals. On the other hand, administration of PC to the poisoned rats did not enhance the levels of the drug-metabolizing enzyme activities except for aminopyrine N-demethylase. Phospholipid phosphorous content, however, increased by 13-14% when PC was given. Thus, it is considered that PC may enhance the reconstitution of phospholipids in the injured membrane.

• 社団法人 日本薬理学会の論文

著者

• KOBAYASHI Takashi

  Gifu Pharmaceutical University

• OGISO Taro

  Gifu College of Pharmacy

• KATO Yoshio

  Gifu College of Pharmacy

• KUHARA Kazunori

  Gifu College of Pharmacy

• KOBAYASHI Takashi

  Gifu College of Pharmacy

関連論文

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• ANTITUMOR AGENTS. II. EFFECT OF 5-FLUOROURACIL AND CYCLOPHOSPHAMIDE ON IMMUNOLOGICAL PARAMETERS AND LIVER MICROSOMES OF TUMOR-BEARING RATS
• EFFECT OF “DRUGS FOR LIVER DISEASE” ON HEPATOTOXIC ACTION OF CARBON TETRACHLORIDE : II. EFFECT OF PROTOPORPHYRIN AND PHOSPHORYLCHOLINE ON MICROSOMAL DRUG-METABOLIZING ENZYME ACTIVITIES AND THE COMPONENTS IN INJURED LIVER
• EFFECT OF “DRUGS FOR LIVER DISEASE” ON HEPATOTOXIC ACTION OF CARBON TETRACHLORIDE : I. CHANGES OF LYSOSOMAL ENZYME LEVELS AND EFFECT OF PROTOPORPHYRIN ON THE LEVELS

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