EFFECTS OF S-8527 (1, 1-BIS [4;-(1″-CARBOXY-1″-METHYLPROPOXY) PHENYL] CYCLOHEXANE), A NEW HYPOLIPIDEMIC COMPOUND, ON PLATELET AGGREGATION, ADHESIVENESS AND BLOOD COAGULATION IN RATS

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Effects of S-8527 (1, l-bis[4-(1″-carboxy-l″-methylpropoxy) phenyl] cyclohexane) on platelet aggregation, adhesiveness and blood coagulation were examined in rats. In animals maintained on a semisynthetic diet containing sucrose (62%) as the only carbohydrate source, platelet adhesiveness increased as compared with that in rats fed a normal chow pellet. Under these experimental conditions, oral dose of S-8527 (30-300 mg/kg) for 14 days decreased platelet adhesiveness and ADP-induced platelet aggregation, but did not decrease collagen-induced platelet aggregation. S-8527 also showed a slight but significant increase of R value of thrombelastograph. In rats which were fed a normal chow pellet oral dose of S-8527 for 14 days did not significantly affect the several tests of platelet function and blood coagulation. These results suggest that S-8527 normalizes the platelet function in a hyper-adhesive state, but does not affect the platelet function in a normal state.
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