THE STIMULATORY EFFECT OF THE BOILED SUPERNATANT ON CYCLIC AMP FORMATION IN SYNAPTOSOMES FROM RAT CEREBRAL CORTEX

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概要

• 論文の詳細を見る

• The effect of the boiled supernatant on synaptosomal adenyl cyclase activity of rat cerebral cortex was investigated. The boiled supernatant markedly increased the accumulation of cyclic AMP in synaptosomes when added to adenyl cyclase system by a mechanism presumably unrelated to inhibition of cyclic AMP phosphodiesterase or adenosine triphosphatase. Magnesium ion was required for synaptosomal adenyl cyclase activity and its stimulation by the boiled supernatant. The result discerned by double reciprocal plots showed an increase in Vmax value of adenyl cyclase by addition of the boiled supernatant without significantly altering the affinity for substrate. The enzyme activity was not stimulated by dopamine, histamine and serotonin in either the absence and presence of the boiled supernatant.

• 社団法人 日本薬理学会の論文

著者

• IZUMI Hiroshi

  Pharmaceutical Institute, Tohoku University

• OZAWA Hikaru

  Pharmaceutical Institute, Tohoku University

• OYAMA Hideko

  Pharmaceutical Institute, Tohoka University

• OZAWA Hikaru

  Pharmaceutical Institute, Tohoka University

• IZUMI Hiroshi

  Pharmaceutical Institute, Tohoka University

• OYAMA Hideko

  Pharmaceutical Institute, Tohoku University

関連論文

• EFFECTS OF VARIOUS AGENTS ON SYNAPTOSOMAL ADENYLATE CYCLASE ACTIVITY IN THE ABSENCE AND PRESENCE OF THE BOILED SUPERNATANT
• DIFFERENT PATTERNS OF INHIBITION OF DOPAMINE-β-HYDROXYLASE BY CYSTEINE
• THE STIMULATORY EFFECT OF THE BOILED SUPERNATANT ON CYCLIC AMP FORMATION IN SYNAPTOSOMES FROM RAT CEREBRAL CORTEX
• STUDIES ON 3, 7-DIMETHYL-1- (5-0X0-HEXYL) -XANTHINE (BL 191) : THE INHIBITORY EFFECT OF BL 191 ON PDE IN VARIOUS TISSUES OF RATS

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