STUDIES OF URCHI-TOXINS: SEPARATION, PURIFICATION AND PHARMACOLOGICAL ACTIONS OF TOXINIC SUBSTANCES
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概要
- 論文の詳細を見る
Urchi-toxins (crude Urchi-toxin F<SUB>2</SUB> and Urchi-toxins F<SUB>3</SUB>, F<SUB>4</SUB> and F<SUB>5</SUB>) derived from Toxopneustes pileolus were investigated physicochemically and pharmacologically. F<SUB>2</SUB>2 was found to be a mixture of several substances (F<SUB>3</SUB>, F<SUB>4</SUB> and F<SUB>5</SUB>) being basic peptides or proteins. F<SUB>2</SUB> and F<SUB>3</SUB> inhibited strongly and slightly the cardiac movement of experimental animals, respectively, while F<SUB>4</SUB> and F<SUB>5</SUB> rather stimulated the heart beat. F<SUB>2</SUB> and F<SUB>3</SUB> elicited remarkable contraction of the small intestine. F<SUB>2</SUB>, F<SUB>3</SUB> and F<SUB>5</SUB> stimulated contraction of the uterus. Actions of F<SUB>2</SUB> on smooth muscles were inactivated by chymotrypsin.
- 社団法人 日本薬理学会の論文
著者
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KIMURA Akira
Training School for Nurse Teachers and Department of Pharmacology, School of Medicine
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HAYASHI Hiromi
Training School for Nurse Teachers and Department of Pharmacology, School of Medicine
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KURAMOTO Masaaki
Training School for Nurse Teachers and Department of Pharmacology, School of Medicine