PHARMACOKINETIC STUDIES ON THE HEPATOTOXICITY OF LUTEOSKYRIN. (1) INTRACELLULAR DISTRIBUTION OF RADIOACTIVITY IN THE LIVER OF MICE ADMINISTERED <SUP>3</SUP>H-LUTEOSKYRIN

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概要

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• Intracellular distribution of the radioactivity derived from <SUP>3</SUP>H-luteoskyrin in mouse liver was investigated. It was revealed that luteoskyrin has a high affinity to mitochondria and cell debris of mouse liver cells. This characteristic distribution pattern in the liver cells may be responsible for the mitochondrial impairment and the age and sex differences in the susceptibility of mice to this mycotoxin.

著者

• UENO Ikuko

  Institute of Medical Sciences, University of Tokyo

• UENO Yoshio

  Microbial Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science

• HAYASHI Tomiko

  Microbial Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science

• UENO Ikuko

  Institute of Medical Science, University of Tokyo

関連論文

• TOXICOLOGICAL APPROACHES TO THE METABOLITES OF FUSARIA. XIII. HEMATOLOGICAL CHANGES IN MICE BY A SINGLE AND REPEATED ADMINISTRATIONS OF TRICHOTHECENES
• PHARMACOKINETIC STUDIES ON THE HEPATOTOXICITY OF LUTEOSKYRIN. (1) INTRACELLULAR DISTRIBUTION OF RADIOACTIVITY IN THE LIVER OF MICE ADMINISTERED 3H-LUTEOSKYRIN
• TOXICOLOGICAL APPROACHES TO THE TOXIC METABOLITES OF FUSARIA VIII. ACUTE AND SUBACUTE TOXICITIES OF T-2 TOXIN IN CATS
• PHARMACOKINETIC STUDIES ON THE HEPATOTOXICITY OF LUTEOSKYRIN (II) EXTRACTION AND IDENTIFICATION OF 3H-LUTEOSKYRIN FROM THE LIVER AND EXCRETA IN MICE

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